Luteinizing hormone/choriogonadotropin receptor

LHCGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LUT, 1XUL
Identifiers
Aliases	LHCGR, HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5, Luteinizing hormone/choriogonadotropin receptor
External IDs	OMIM: 152790 MGI: 96783 HomoloGene: 37276 GeneCards: LHCGR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	48,755,730 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	89,099,418 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; adipose tissue; ; stromal cell of endometrium; ; subcutaneous adipose tissue; ; abdominal fat; ; trigeminal ganglion; ; right adrenal gland; ; urinary bladder; ; spinal ganglia;
	Top expressed in
	ovary; ; spermatocyte; ; testicle; ; superior frontal gyrus; ; rhombencephalon; ; mesencephalon; ; piriform cortex; ; hippocampal formation; ; adrenal gland; ; muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; choriogonadotropin hormone binding; signal transducer activity; protein-hormone receptor activity; choriogonadotropin hormone receptor activity; follicle-stimulating hormone receptor activity; luteinizing hormone receptor activity;
Cellular component	integral component of membrane; endosome; membrane; integral component of plasma membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; male gonad development; male genitalia development; cognition; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; activation of adenylate cyclase activity; positive regulation of inositol trisphosphate biosynthetic process; hormone-mediated signaling pathway; cellular response to gonadotropin stimulus; signal transduction; primary ovarian follicle growth; phospholipase C-activating G protein-coupled receptor signaling pathway; follicle-stimulating hormone signaling pathway; regulation of osteoclast differentiation; luteinizing hormone signaling pathway; positive regulation of adenylate cyclase activity; cellular response to luteinizing hormone stimulus; adenylate cyclase-activating G protein-coupled receptor signaling pathway; ovulation cycle process;
	Sources:Amigo / QuickGO
Orthologs
	3973
	16867
	ENSG00000138039
	ENSMUSG00000024107
	P22888
	P30730
	NM_000233
	NM_013582; NM_001364898
	NP_000224
	NP_038610; NP_001351827
	Wikidata
View/Edit Human	View/Edit Mouse

The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR), is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.

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