Low-affinity nerve growth factor receptor

NGFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EWV, 2N80, 2N97, 2N83
Identifiers
Aliases	NGFR, CD271, Gp80-LTNFRSF16, p75(NTR), p75NTR, nerve growth factor receptor
External IDs	OMIM: 162010 MGI: 97323 HomoloGene: 1877 GeneCards: NGFR
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,515,008 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,478,561 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; spinal ganglia; ; sural nerve; ; right lobe of thyroid gland; ; trigeminal ganglion; ; left uterine tube; ; left lobe of thyroid gland; ; left coronary artery; ; olfactory bulb; ; right lobe of liver;
	Top expressed in
	spinal ganglia; ; submandibular gland; ; external carotid artery; ; cervix; ; internal carotid artery; ; trigeminal ganglion; ; maxillary prominence; ; neural tube; ; dermis; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding; protein binding; calmodulin binding; coreceptor activity; neurotrophin binding; nerve growth factor binding; amyloid-beta binding; death receptor activity; signaling receptor activity;
Cellular component	extracellular region; nucleoplasm; integral component of membrane; cytosol; integral component of plasma membrane; neuron projection; membrane; cell surface; endosome; nucleus; plasma membrane;
Biological process	rhythmic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; neurotrophin TRK receptor signaling pathway; signal transduction; axon guidance; multicellular organism development; apoptotic process; negative regulation of axonogenesis; nervous system development; glucose homeostasis; positive regulation of axonogenesis; circadian regulation of gene expression; membrane protein intracellular domain proteolysis; cell differentiation; inflammatory response; immune response; intracellular protein transport; positive regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; tumor necrosis factor-mediated signaling pathway; response to lipopolysaccharide; apoptotic signaling pathway; negative regulation of neuron projection development; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein localization to nucleus; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; Rho protein signal transduction; cellular glucose homeostasis; neuron apoptotic process; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4804
	18053
	ENSG00000064300
	ENSMUSG00000000120
	P08138
	Q9Z0W1
	NM_002507
	NM_033217
	NP_002498
	NP_150086
	Wikidata
View/Edit Human	View/Edit Mouse

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.

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