Liver X receptor alpha

NR1H3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS
Identifiers
Aliases	NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3
External IDs	OMIM: 602423 MGI: 1352462 HomoloGene: 21165 GeneCards: NR1H3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,269,032 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,033,179 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; spleen; ; tibial nerve; ; subcutaneous adipose tissue; ; canal of the cervix; ; gallbladder; ; lymph node; ; right lobe of thyroid gland; ; gastric mucosa; ; right uterine tube;
	Top expressed in
	left lobe of liver; ; proximal tubule; ; brown adipose tissue; ; white adipose tissue; ; subcutaneous adipose tissue; ; duodenum; ; yolk sac; ; jejunum; ; spleen; ; female urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; zinc ion binding; nuclear receptor activity; sterol response element binding; steroid hormone receptor activity; DNA binding; sequence-specific DNA binding; metal ion binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator activity; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	receptor complex; nucleoplasm; RNA polymerase II transcription regulator complex; nucleus; cytoplasm;
Biological process	positive regulation of toll-like receptor 4 signaling pathway; sterol homeostasis; negative regulation of pancreatic juice secretion; negative regulation of inflammatory response; cellular response to lipopolysaccharide; negative regulation of lipid transport; positive regulation of lipoprotein lipase activity; lipid homeostasis; triglyceride homeostasis; negative regulation of macrophage activation; negative regulation of macrophage derived foam cell differentiation; positive regulation of cholesterol transport; negative regulation of cholesterol storage; regulation of transcription, DNA-templated; positive regulation of triglyceride biosynthetic process; positive regulation of cholesterol efflux; positive regulation of protein metabolic process; negative regulation of interferon-gamma-mediated signaling pathway; regulation of circadian rhythm; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; response to progesterone; steroid hormone mediated signaling pathway; apoptotic cell clearance; positive regulation of fatty acid biosynthetic process; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; negative regulation of secretion of lysosomal enzymes; negative regulation of pinocytosis; positive regulation of transcription, DNA-templated; intracellular receptor signaling pathway; cholesterol homeostasis; lipid metabolism; multicellular organism development; cell differentiation; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10062
	22259
	ENSG00000025434
	ENSMUSG00000002108
	Q13133
	Q9Z0Y9
	NM_001130101; NM_001130102; NM_001251934; NM_001251935; NM_005693
	NM_001177730; NM_013839; NM_001355279
NP_001123573; NP_001123574; NP_001238863; NP_001238864; NP_005684;
	NP_001350524; NP_005684.2
	NP_001171201; NP_038867; NP_001342208
	Wikidata
View/Edit Human	View/Edit Mouse

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.