Levamisole

Levamisole, sold under the brand name Ergamisol among others, is a medication used to treat parasitic worm infections, specifically ascariasis and hookworm infections. It is taken by mouth.

Levamisole
Clinical data
Trade namesDecaris, Ergamisol
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa697011
License data
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • CA: Withdrawn drug
  • US: Withdrawn
  • Rx-only (RU)
Pharmacokinetic data
MetabolismLiver
Elimination half-life3–4 hours
ExcretionUrine (70%)
Identifiers
  • (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b] [1,3]thiazole
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.035.290
Chemical and physical data
FormulaC11H12N2S
Molar mass204.29 g·mol−1
3D model (JSmol)
Density1.31 g/cm3
Melting point60 °C (140 °F)
Solubility in waterhydrochloride: 210 mg/mL (20 °C)
  • N\2=C1/SCCN1C[C@@H]/2c3ccccc3
  • InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1 Y
  • Key:HLFSDGLLUJUHTE-SNVBAGLBSA-N Y
 NY (what is this?)  (verify)

Side effects may include abdominal pain, vomiting, headache, and dizziness. Use is not recommended during breastfeeding or the third trimester of pregnancy. Serious side effects may include an increased risk of infection. It belongs to the anthelmintic class of medications.

Levamisole was invented in 1966 in Belgium by Janssen Pharmaceuticals. It is on the World Health Organization's List of Essential Medicines. Levamisole is also used as a dewormer for cattle.

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