Lenalidomide

Lenalidomide
Clinical data
Pronunciation	/ˌlɛnəˈlɪdoʊmaɪd/
Trade names	Revlimid, Linamide, others
AHFS/Drugs.com	Monograph
MedlinePlus	a608001
License data	EU EMA: by INN; US DailyMed: Lenalidomide;
Pregnancy; category	AU: X (High risk);
Routes of; administration	By mouth
ATC code	L04AX04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C3 (Immunosuppressive drugs); UK: POM (Prescription only); US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	Undetermined
Protein binding	30%
Metabolism	Undetermined
Elimination half-life	3 hours
Excretion	Kidney (67% unchanged)
Identifiers
	IUPAC name (3RS)-3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione;
CAS Number	191732-72-6 ;
PubChem CID	216326;
IUPHAR/BPS	7331;
DrugBank	DB00480 ;
ChemSpider	187515 ;
UNII	F0P408N6V4;
KEGG	D04687 ;
ChEMBL	ChEMBL848 ;
CompTox Dashboard (EPA)	DTXSID8046664 ;
ECHA InfoCard	100.218.924
Chemical and physical data
Formula	C13H13N3O3
Molar mass	259.265 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C1NC(=O)CCC1N3C(=O)c2cccc(c2C3)N;
	InChI InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) ; Key:GOTYRUGSSMKFNF-UHFFFAOYSA-N ;
	(verify)

Lenalidomide, sold under the brand name Revlimid among others, is a medication used to treat multiple myeloma, smoldering myeloma, and myelodysplastic syndromes (MDS). For multiple myeloma, it is a first line treatment, and is given with dexamethasone. It is taken by mouth.

Common side effects include diarrhea, itchiness, joint pain, fever, headache, and trouble sleeping. Severe side effects include low blood platelets, low white blood cells, and blood clots. Use during pregnancy may harm the fetus. The dose may need to be adjusted in people with kidney problems. It has a chemical structure similar to thalidomide but has a different mechanism of action. How it works is not entirely clear as of 2019.

Lenalidomide was approved for medical use in the United States in 2005. It is on the World Health Organization's List of Essential Medicines.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.