Leukotriene C4 synthase

LTC4S
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JRZ, 2PNO, 2UUH, 2UUI, 3B29, 3HKK, 3LEO, 3PCV, 4J7T, 4J7Y, 4JC7, 4JCZ, 5HV9, 4WAB
Identifiers
Aliases	LTC4S, entrez:4056, Leukotriene C4 synthase
External IDs	OMIM: 246530 MGI: 107498 HomoloGene: 7406 GeneCards: LTC4S
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,796,647 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,129,443 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right coronary artery; ; left uterine tube; ; left coronary artery; ; right lung; ; tibial nerve; ; ascending aorta; ; spleen; ; blood; ; myometrium;
	Top expressed in
	white adipose tissue; ; subcutaneous adipose tissue; ; brown adipose tissue; ; ankle joint; ; secondary oocyte; ; lip; ; superior frontal gyrus; ; entorhinal cortex; ; thymus; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	leukotriene-C4 synthase activity; glutathione peroxidase activity; protein binding; lyase activity; enzyme activator activity; lipid binding; identical protein binding; glutathione transferase activity;
Cellular component	integral component of membrane; membrane; nuclear envelope; endoplasmic reticulum; nuclear outer membrane; nucleus; intracellular membrane-bounded organelle; endoplasmic reticulum membrane;
Biological process	positive regulation of catalytic activity; leukotriene biosynthetic process; cellular oxidant detoxification; leukotriene metabolic process; long-chain fatty acid biosynthetic process; lipoxygenase pathway; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4056
	17001
	ENSG00000283887; ENSG00000213316
	ENSMUSG00000020377
	Q16873
	Q60860
	NM_145867; NM_000897
	NM_008521; NM_001313968
	NP_665874
	NP_001300897; NP_032547
	Wikidata
View/Edit Human	View/Edit Mouse

Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein. This protein is remotely related to microsomal glutathione S-transferase.

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