LIG1

LIG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X9N
Identifiers
Aliases	LIG1, DNA ligase 1, LIGI, hLig1, IMD96
External IDs	OMIM: 126391 MGI: 101789 HomoloGene: 197 GeneCards: LIG1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,170,603 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	13,045,350 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ganglionic eminence; ; sural nerve; ; skin of abdomen; ; lymph node; ; spleen; ; rectum; ; left lobe of thyroid gland; ; body of pancreas; ; bone marrow cells;
	Top expressed in
	outer renal medulla; ; inner renal medulla; ; primitive streak; ; somite; ; yolk sac; ; maxillary prominence; ; dermis; ; internal carotid artery; ; abdominal wall; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; DNA ligase (ATP) activity; metal ion binding; ligase activity; ATP binding; DNA ligase activity;
Cellular component	intracellular membrane-bounded organelle; nucleoplasm; mitochondrion; nucleus; cytoplasm;
Biological process	nucleotide-excision repair, DNA gap filling; DNA recombination; DNA biosynthetic process; anatomical structure morphogenesis; Okazaki fragment processing involved in mitotic DNA replication; cellular response to DNA damage stimulus; cell division; DNA replication; V(D)J recombination; DNA mismatch repair; DNA ligation involved in DNA repair; cell cycle; transcription-coupled nucleotide-excision repair; DNA repair; base-excision repair; DNA ligation; lagging strand elongation;
	Sources:Amigo / QuickGO
Orthologs
	3978
	16881
	ENSG00000105486
	ENSMUSG00000056394
	P18858
	P37913
	NM_000234; NM_001289063; NM_001289064; NM_001320970; NM_001320971
	NM_001083188; NM_001199310; NM_010715
	NP_000225; NP_001275992; NP_001275993; NP_001307899; NP_001307900
	NP_001076657; NP_001186239; NP_034845
	Wikidata
View/Edit Human	View/Edit Mouse

DNA ligase 1 is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase I is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.