KCNA3

KCNA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BGC
Identifiers
Aliases	KCNA3, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3
External IDs	OMIM: 176263 MGI: 96660 HomoloGene: 128570 GeneCards: KCNA3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,674,940 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	106,945,386 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; lymph node; ; monocyte; ; blood; ; appendix; ; ganglionic eminence; ; superficial temporal artery; ; rectum; ; prefrontal cortex; ; islet of Langerhans;
	Top expressed in
	thymus; ; ganglionic eminence; ; superior frontal gyrus; ; superior colliculus; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; dorsal tegmental nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	outward rectifier potassium channel activity; potassium channel activity; voltage-gated ion channel activity; ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; protein binding;
Cellular component	membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; axon; membrane raft; integral component of membrane; calyx of Held; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; protein homooligomerization; potassium ion transmembrane transport; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3738
	16491
	ENSG00000177272
	ENSMUSG00000047959
	P22001
	P16390
	NM_002232
	NM_008418
	NP_002223
	NP_032444
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K_v1.3, is a protein that in humans is encoded by the KCNA3 gene.

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s).

This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T cell proliferation and activation. This gene appears to be intronless and is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

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