JWH-373

JWH-373
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name [5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone;
CAS Number	914458-37-0 ;
PubChem CID	44418316;
ChemSpider	23277894 ;
Chemical and physical data
Formula	C30H33NO
Molar mass	423.600 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C=1C=C(C=2C=CC(=CC2)CCCC)N(C1)CCCCC)C3=CC=CC=4C=CC=CC43;
	InChI InChI=1S/C30H33NO/c1-3-5-11-20-31-22-25(21-29(31)27-18-10-8-15-24(27)13-6-4-2)30(32)28-19-12-16-23-14-7-9-17-26(23)28/h7-10,12,14-19,21-22H,3-6,11,13,20H2,1-2H3 ; Key:LDGBUSJKRUNXPK-UHFFFAOYSA-N ;

JWH-373 ([5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 60 ± 3nM) and CB₂ (K_i = 69 ± 2nM) receptors, with a slight selectivity for the former. JWH-373 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

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