JWH-370

JWH-370
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name [5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone;
CAS Number	914458-22-3 ;
PubChem CID	44418312;
ChemSpider	23277889 ;
UNII	HJZ9JN4HNM;
Chemical and physical data
Formula	C27H27NO
Molar mass	381.519 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2C)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C27H27NO/c1-3-4-9-17-28-19-22(18-26(28)23-14-7-5-11-20(23)2)27(29)25-16-10-13-21-12-6-8-15-24(21)25/h5-8,10-16,18-19H,3-4,9,17H2,1-2H3 ; Key:HZMLAMXVETUEJZ-UHFFFAOYSA-N ;

JWH-370 ([5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 5.6 ± 0.4nM) and CB₂ (K_i = 4.0 ± 0.5nM) receptors, with a slight selectivity for the CB₂ receptor. JWH-370 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

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