JWH-366

JWH-366
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name naphthalen-1-yl-(1-pentyl-5-pyridin-3-ylpyrrol-3-yl)methanone;
CAS Number	914458-44-9 ;
PubChem CID	44418373;
ChemSpider	23277955 ;
Chemical and physical data
Formula	C25H24N2O
Molar mass	368.480 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C=C(C=C1C2=CN=CC=C2)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C25H24N2O/c1-2-3-6-15-27-18-21(16-24(27)20-11-8-14-26-17-20)25(28)23-13-7-10-19-9-4-5-12-22(19)23/h4-5,7-14,16-18H,2-3,6,15H2,1H3 ; Key:MPQYTRCOFXNOTB-UHFFFAOYSA-N ;

JWH-366 (naphthalen-1-yl-(1-pentyl-5-pyridin-3-ylpyrrol-3-yl)methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 191 ± 12nM) and CB₂ (K_i = 24 ± 1nM) receptors, with a strong (~8x) selectivity for the CB₂ receptor over the CB₁ receptor. JWH-366 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

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