JWH-365

JWH-365
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name (5-(2-Ethylphenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone;
CAS Number	914458-23-4 ;
PubChem CID	44418313;
ChemSpider	23277890 ;
Chemical and physical data
Formula	C28H29NO
Molar mass	395.546 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2CC)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C28H29NO/c1-3-5-10-18-29-20-23(19-27(29)25-16-9-6-12-21(25)4-2)28(30)26-17-11-14-22-13-7-8-15-24(22)26/h6-9,11-17,19-20H,3-5,10,18H2,1-2H3 ; Key:SNWJCZXZSGPAJM-UHFFFAOYSA-N ;

JWH-365 ((5-(2-Ethylphenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 17 ± 1nM) and CB₂ (K_i = 3.4 ± 0.2nM) receptors, with a strong (~5x) selectivity for the CB₂ receptor over the CB₁ receptor. JWH-365 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

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