JWH-309

JWH-309
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name naphthalen-1-yl-(5-naphthalen-1-yl-1-pentylpyrrol-3-yl)methanone;
CAS Number	914458-42-7 ;
PubChem CID	44418371;
ChemSpider	ID23277951 ;
UNII	5LC7L6AM73;
Chemical and physical data
Formula	C30H27NO
Molar mass	417.552 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C=C(C=C1C2=CC=CC3=CC=CC=C32)C(=O)C4=CC=CC5=CC=CC=C54;
	InChI InChI=1S/C30H27NO/c1-2-3-8-19-31-21-24(30(32)28-18-10-14-23-12-5-7-16-26(23)28)20-29(31)27-17-9-13-22-11-4-6-15-25(22)27/h4-7,9-18,20-21H,2-3,8,19H2,1H3 ; Key:WVISOUYKTUUDFW-UHFFFAOYSA-N ;

JWH-309 (naphthalen-1-yl-(5-naphthalen-1-yl-1-pentylpyrrol-3-yl)methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 41 ± 3nM) and CB₂ (K_i = 49 ± 7nM) receptors, displaying a slight selectivity for the former. JWH-309 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

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