JWH-048

JWH-048
Legal status
Legal status	US: Schedule I;
Identifiers
	IUPAC name (1-Pentyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone;
CAS Number	316189-66-9 ;
PubChem CID	11280135;
ChemSpider	9455134;
UNII	ZLS6Q88UQ8;
Chemical and physical data
Formula	C26H27NO
Molar mass	369.508 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=C3C=C(C=C4)C)C;
	InChI InChI=1S/C26H27NO/c1-4-5-8-16-27-19(3)25(22-11-6-7-13-24(22)27)26(28)21-12-9-10-20-15-14-18(2)17-23(20)21/h6-7,9-15,17H,4-5,8,16H2,1-3H3; Key:HSGMJSSWGKDWNA-UHFFFAOYSA-N;

JWH-048 is a selective cannabinoid ligand, with a bindining affinity of K_i = 0.5 ± 0.1 nM for the CB₂ subtype, and more than 22 times selectivity over the CB₁.

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-048 are Schedule I Controlled Substances.

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