JWH-047

JWH-047
Legal status
Legal status	US: Schedule I;
Identifiers
	IUPAC name (1-Butyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone;
CAS Number	316189-65-8 ;
ChemSpider	35303438;
UNII	8DQF9PUT4F;
Chemical and physical data
Formula	C25H25NO
Molar mass	355.481 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCn1c(c(c2c1cccc2)C(=O)c3cccc4c3cc(cc4)C)C;
	InChI InChI=1S/C25H25NO/c1-4-5-15-26-18(3)24(21-10-6-7-12-23(21)26)25(27)20-11-8-9-19-14-13-17(2)16-22(19)20/h6-14,16H,4-5,15H2,1-3H3; Key:RQWLYQGWFKBOIY-UHFFFAOYSA-N;

JWH-047 is a selective cannabinoid ligand that binds to both CB₁ and CB₂. It has a bindining affinity of K_i = 0.9 nM for the CB₂ subtype, and more than 65 times selectivity over the CB₁.

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-047 are Schedule I Controlled Substances.

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