JWH-015

JWH-015
Legal status
Legal status	CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I;
Identifiers
	IUPAC name (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone;
CAS Number	155471-08-2 ;
PubChem CID	4273754;
IUPHAR/BPS	5558;
ChemSpider	3480676 ;
UNII	W4FL204T10;
CompTox Dashboard (EPA)	DTXSID60165902 ;
ECHA InfoCard	100.161.912
Chemical and physical data
Formula	C23H21NO
Molar mass	327.427 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43)C;
	InChI InChI=1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3 ; Key:LJSBBBWQTLXQEN-UHFFFAOYSA-N ;
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JWH-015 is a chemical from the naphthoylindole family that acts as a subtype-selective cannabinoid agonist. Its affinity for CB₂ receptors is 13.8 nM, while its affinity for CB₁ is 383 nM, meaning that it binds almost 28 times more strongly to CB₂ than to CB₁. However, it still displays some CB₁ activity, and in some model systems can be very potent and efficacious at activating CB₁ receptors, and therefore it is not as selective as newer drugs such as JWH-133. It has been shown to possess immunomodulatory effects, and CB₂ agonists may be useful in the treatment of pain and inflammation. It was discovered and named after John W. Huffman.

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