Isopentenyl-diphosphate delta isomerase
Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase, is an isomerase that catalyzes the conversion of the relatively un-reactive isopentenyl pyrophosphate (IPP) to the more-reactive electrophile dimethylallyl pyrophosphate (DMAPP). This isomerization is a key step in the biosynthesis of isoprenoids through the mevalonate pathway and the MEP pathway.
- isopentenyl diphosphate dimethylallyl diphosphate
| isopentenyl-diphosphate Δ-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Isopentenyl-diphosphate delta isomerase octamer, Thermus thermophilus | |||||||||
| Identifiers | |||||||||
| EC no. | 5.3.3.2 | ||||||||
| CAS no. | 9033-27-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Isopentenyl-pyrophosphate Δ isomerase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IDI1 | ||||||
| NCBI gene | 3422 | ||||||
| HGNC | 5387 | ||||||
| OMIM | 604055 | ||||||
| RefSeq | NM_004508 | ||||||
| UniProt | Q13907 | ||||||
| Other data | |||||||
| EC number | 5.3.3.2 | ||||||
| Locus | Chr. 10 p15.3 | ||||||
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This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is isopentenyl-diphosphate Delta3-Delta2-isomerase. Other names in common use include isopentenylpyrophosphate Delta-isomerase, methylbutenylpyrophosphate isomerase, and isopentenylpyrophosphate isomerase.