FNDC5

FNDC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LSD
Identifiers
Aliases	FNDC5, FRCP2, irisin, Irisin, fibronectin type III domain containing 5
External IDs	OMIM: 611906 MGI: 1917614 HomoloGene: 17812 GeneCards: FNDC5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,872,482 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,038,386 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; gastrocnemius muscle; ; deltoid muscle; ; tibialis anterior muscle; ; left ventricle; ; body of tongue; ; parotid gland; ; prefrontal cortex; ; cingulate gyrus; ; Brodmann area 9;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cerebellar cortex; ; soleus muscle; ; extraocular muscle; ; medial vestibular nucleus; ; superior frontal gyrus; ; digastric muscle; ; cerebellar vermis; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; molecular function;
Cellular component	integral component of membrane; extracellular region; peroxisomal membrane; peroxisome; membrane; endoplasmic reticulum; plasma membrane;
Biological process	response to muscle activity; positive regulation of brown fat cell differentiation; regulation of signaling receptor activity; biological process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	252995
	384061
	ENSG00000160097
	ENSMUSG00000001334
	Q8NAU1
	Q8K4Z2
	NM_153756; NM_001171940; NM_001171941
	NM_027402
	NP_001165411; NP_001165412; NP_715637
	NP_081678
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris.

Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a ~100 kDa fibronectin type III (FNIII) domain.

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