CD74

CD74
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W
Identifiers
Aliases	CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
External IDs	OMIM: 142790 MGI: 96534 HomoloGene: 3209 GeneCards: CD74
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,412,969 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	60,945,724 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; spleen; ; lymph node; ; right lung; ; gallbladder; ; upper lobe of left lung; ; lower lobe of lung; ; jejunal mucosa; ; right coronary artery;
	Top expressed in
	spleen; ; jejunum; ; thymus; ; ileum; ; zone of skin; ; colon; ; lip; ; uterus; ; adrenal gland; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nitric-oxide synthase binding; identical protein binding; MHC class II protein binding, via antigen binding groove; cytokine receptor activity; macrophage migration inhibitory factor binding; protein folding chaperone activity; MHC class II protein complex binding; amyloid-beta binding; protein binding; MHC class II protein binding; cytokine binding; CD4 receptor binding;
Cellular component	lysosomal lumen; extracellular exosome; MHC class II protein complex; lysosomal membrane; late endosome; endocytic vesicle membrane; transport vesicle membrane; integral component of membrane; ER to Golgi transport vesicle membrane; multivesicular body; Golgi apparatus; Golgi membrane; trans-Golgi network membrane; macrophage migration inhibitory factor receptor complex; membrane; cell surface; intracellular anatomical structure; integral component of lumenal side of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; lysosome; vacuole; endosome; clathrin-coated endocytic vesicle membrane; NOS2-CD74 complex; external side of plasma membrane;
Biological process	immune response; positive regulation of T cell differentiation; negative regulation of apoptotic process; signal transduction; positive thymic T cell selection; chaperone cofactor-dependent protein refolding; T cell selection; positive regulation of type 2 immune response; positive regulation of dendritic cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; adaptive immune response; antigen processing and presentation; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptotic process; regulation of macrophage activation; negative regulation of DNA damage response, signal transduction by p53 class mediator; immunoglobulin mediated immune response; leukocyte migration; positive regulation of neutrophil chemotaxis; positive regulation of chemokine (C-X-C motif) ligand 2 production; macrophage migration inhibitory factor signaling pathway; prostaglandin biosynthetic process; cell population proliferation; antigen processing and presentation of endogenous antigen; immune system process; defense response; negative regulation of peptide secretion; negative regulation of T cell differentiation; positive regulation of macrophage cytokine production; positive regulation of B cell proliferation; negative thymic T cell selection; positive regulation of fibroblast proliferation; intracellular protein transport; positive regulation of ERK1 and ERK2 cascade; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of cytokine-mediated signaling pathway; positive regulation of protein phosphorylation; positive regulation of kinase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of monocyte differentiation; positive regulation of transcription, DNA-templated; positive regulation of viral entry into host cell; protein heterotetramerization; protein trimerization; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	972
	16149
	ENSG00000019582
	ENSMUSG00000024610
	P04233
	P04441
	NM_004355; NM_001025158; NM_001025159; NM_001364083; NM_001364084
	NM_001042605; NM_010545
	NP_001020329; NP_001020330; NP_004346; NP_001351012; NP_001351013
	NP_001036070; NP_034675
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).

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