Interstate 280 (California)

Interstate 280 (I-280) is a 57.22-mile-long (92.09 km) major north–south auxiliary Interstate Highway in the San Francisco Bay Area of Northern California. It runs from I-680 and US Route 101 (US 101) in San Jose to King and 5th streets in San Francisco, running just to the west of the larger cities of San Francisco Peninsula for most of its route.

From I-880 in San Jose to State Route 1 (SR 1) in Daly City, I-280 was built and dedicated as the Junipero Serra Freeway, after the Spanish Franciscan friar who founded the first nine of 21 Spanish missions in California from San Diego to San Francisco. One of the dedication signs (in Daly City) still indicates that the Junipero Serra Freeway is known as the "World's Most Beautiful Freeway" due to its scenic route through the San Francisco Peninsula. From SR 1 to the James Lick Freeway (US 101) in San Francisco it is officially called the John F. Foran Freeway (after a former member of the California State Legislature). From the James Lick Freeway to its northern end at King and 5th streets, I-280 is called the Southern-Embarcadero Freeway.

I-280 is one of two auxiliary Interstate designations to appear on opposite coasts of the United States. I-110 in California and Florida is the only other designation.

I-280 was formerly shown on the app icon for Apple's iOS and macOS built-in Apple Maps. This is because the highway goes through Cupertino, the home of Apple's headquarters.