Interleukin 13 receptor, alpha 1

IL13RA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BPN, 3BPO, 4HWB, 5E4E
Identifiers
Aliases	IL13RA1, CD213A1, IL-13Ra, NR4, CT19, interleukin 13 receptor subunit alpha 1
External IDs	OMIM: 300119 MGI: 105052 HomoloGene: 1198 GeneCards: IL13RA1
Gene location (Human)
Chr.	X chromosome (human)
End	118,794,535 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	35,434,912 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; parietal pleura; ; visceral pleura; ; synovial joint; ; germinal epithelium; ; rectum; ; monocyte; ; lower lobe of lung; ; tibia; ; saphenous vein;
	Top expressed in
	jejunum; ; left colon; ; duodenum; ; Paneth cell; ; renal corpuscle; ; proximal tubule; ; ileum; ; conjunctival fornix; ; intestinal villus; ; cervix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein binding; interleukin-13 receptor activity; cytokine binding;
Cellular component	integral component of membrane; interleukin-13 receptor complex; plasma membrane; membrane; external side of plasma membrane; receptor complex;
Biological process	cell surface receptor signaling pathway; cytokine-mediated signaling pathway; interleukin-13-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3597
	16164
	ENSG00000131724
	ENSMUSG00000017057
	P78552
	O09030
	NM_001560
	NM_133990
	NP_001551
	NP_598751
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

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