Interleukin 8

CXCL8
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX
Identifiers
Aliases	CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8
External IDs	OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,743,716 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; monocyte; ; bone marrow cells; ; sperm; ; gallbladder; ; mucosa of urinary bladder; ; bronchus; ; bronchial epithelial cell; ; trachea; ; vena cava;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding; interleukin-8 receptor binding; chemokine activity;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; intracellular signal transduction; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; receptor internalization; cellular response to fibroblast growth factor stimulus; response to endoplasmic reticulum stress; positive regulation of angiogenesis; regulation of single stranded viral RNA replication via double stranded DNA intermediate; PERK-mediated unfolded protein response; induction of positive chemotaxis; chemotaxis; regulation of cell adhesion; immune response; cellular response to interleukin-1; angiogenesis; positive regulation of neutrophil chemotaxis; inflammatory response; negative regulation of G protein-coupled receptor signaling pathway; response to molecule of bacterial origin; cellular response to lipopolysaccharide; embryonic digestive tract development; signal transduction; negative regulation of cell population proliferation; calcium-mediated signaling; regulation of entry of bacterium into host cell; defense response; neutrophil chemotaxis; neutrophil activation; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; cytokine-mediated signaling pathway; leukocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	3576
	n/a
	ENSG00000169429
	n/a
	P10145
	n/a
	NM_000584; NM_001354840
	n/a
	NP_000575; NP_001341769
	n/a
	Wikidata
View/Edit Human

Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.

There are many receptors on the surface membrane capable of binding IL-8; the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.

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