Interleukin 3

IL3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1JLI
Identifiers
Aliases	IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
External IDs	OMIM: 147740 HomoloGene: 47938 GeneCards: IL3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,063,204 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; bone marrow; ; lymph node; ; appendix;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; interleukin-3 receptor binding; cytokine activity; protein tyrosine kinase activity; interleukin-1 receptor binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	MAPK cascade; embryonic hemopoiesis; cell-cell signaling; nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; immune response; peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; fever generation; regulation of cytokine-mediated signaling pathway; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3562
	n/a
	ENSG00000164399
	n/a
	P08700
	n/a
	NM_000588
	n/a
	NP_000579
	n/a
	Wikidata
View/Edit Human

Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain. IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells. The major function of IL-3 cytokine is to regulate the concentrations of various blood-cell types. It induces proliferation and differentiation in both early pluripotent stem cells and committed progenitors. It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype switching.

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