ITPA

ITPA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CAR, 2I5D, 2J4E, 4F95
Identifiers
Aliases	ITPA, C20orf37, HLC14-06-P, dJ794I6.3, My049, ITPase, NTPase, inosine triphosphatase, DEE35
External IDs	OMIM: 147520 MGI: 96622 HomoloGene: 6289 GeneCards: ITPA
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,223,870 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	130,523,534 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; left adrenal gland; ; skin of abdomen; ; minor salivary gland; ; spleen; ; body of stomach; ; monocyte; ; body of pancreas;
	Top expressed in
	endocardial cushion; ; primitive streak; ; morula; ; ganglionic eminence; ; neural tube; ; otic placode; ; maxillary prominence; ; abdominal wall; ; atrioventricular valve; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; dITP diphosphatase activity; XTP diphosphatase activity; ITP diphosphatase activity; hydrolase activity; metal ion binding; nucleotide diphosphatase activity; NADH pyrophosphatase activity; nucleoside-triphosphate diphosphatase activity; identical protein binding;
Cellular component	cytoplasm; cytosol;
Biological process	ITP catabolic process; nucleotide metabolic process; chromosome organization; nucleoside triphosphate catabolic process; purine nucleotide catabolic process; deoxyribonucleoside triphosphate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3704
	16434
	ENSG00000125877
	ENSMUSG00000074797
	Q9BY32
	Q9D892
NM_001267623; NM_033453; NM_181493; NM_001324236; NM_001324237;
	NM_001324238; NM_001324240; NM_001351739
	NM_025922; NM_001362648
NP_001254552; NP_001311165; NP_001311166; NP_001311167; NP_001311169;
	NP_258412; NP_852470; NP_001338668
	NP_080198; NP_001349577
	Wikidata
View/Edit Human	View/Edit Mouse

Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae; the protein is also encoded by some RNA viruses of the Potyviridae family. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.