IFITM3

IFITM3
Identifiers
Aliases	IFITM3, 1-8U, DSPA2b, IP15, interferon induced transmembrane protein 3
External IDs	OMIM: 605579 MGI: 1913391 HomoloGene: 136199 GeneCards: IFITM3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	329,475 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,590,683 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; left coronary artery; ; pericardium; ; ascending aorta; ; upper lobe of left lung; ; right coronary artery; ; canal of the cervix; ; right lung; ; tibial nerve; ; gastric mucosa;
	Top expressed in
	aortic valve; ; right lung lobe; ; carotid body; ; uterus; ; ascending aorta; ; cervix; ; left lobe of liver; ; calvaria; ; ankle joint; ; left lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; endosome; membrane; late endosome membrane; plasma membrane; lysosomal membrane; lysosome; protein-containing complex;
Biological process	negative regulation of viral entry into host cell; response to interferon-gamma; immune system process; response to virus; response to interferon-beta; response to biotic stimulus; negative regulation of viral genome replication; type I interferon signaling pathway; immune response; response to interferon-alpha; innate immune response; negative regulation of viral transcription; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	10410
	66141
	ENSG00000142089
	ENSMUSG00000025492
	Q01628
	Q9CQW9
	NM_021034
	NM_025378
	NP_066362
	NP_079654
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene. It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked. This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1. The prevalence of this mutation is thought to be approximately 1/400 in European populations.

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