ITPK1

ITPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q7D, 2ODT, 2QB5
Identifiers
Aliases	ITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDs	OMIM: 601838 MGI: 2446159 HomoloGene: 8588 GeneCards: ITPK1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	93,116,320 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,671,189 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; nucleus accumbens; ; sural nerve; ; Brodmann area 9; ; right coronary artery; ; caudate nucleus; ; gallbladder; ; monocyte; ; rectum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; intestinal villus; ; ileum; ; duodenum; ; jejunum; ; entorhinal cortex; ; large intestine; ; colon; ; epithelium of stomach; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; isomerase activity; metal ion binding; kinase activity; inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity; catalytic activity; inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity; inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity; inositol-3,4,6-trisphosphate 1-kinase activity; ATP binding; hydrolase activity; magnesium ion binding; inositol-1,3,4-trisphosphate 6-kinase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,3,4-trisphosphate 5-kinase activity; inositol tetrakisphosphate 1-kinase activity; inositol tetrakisphosphate 6-kinase activity;
Cellular component	cytosol; intracellular anatomical structure; apical plasma membrane; cytoplasm;
Biological process	phosphorylation; blood coagulation; inositol phosphate metabolic process; inositol trisphosphate metabolic process; neural tube development; signal transduction; dephosphorylation; necroptosis; inositol phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3705
	217837
	ENSG00000100605; ENSG00000274958
	ENSMUSG00000057963
	Q13572
	Q8BYN3
	NM_014216; NM_001142593; NM_001142594; NM_001363707
	NM_172584
	NP_001136065; NP_001136066; NP_055031; NP_001350636
	NP_766172
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.

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