IL18R1

IL18R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WO3, 3WO4, 4R6U
Identifiers
Aliases	IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1, IL-18R-alpha, IL18Ralpha2, IL-18Ralpha
External IDs	OMIM: 604494 MGI: 105383 HomoloGene: 2861 GeneCards: IL18R1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,398,777 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,540,014 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; blood; ; spleen; ; appendix; ; gallbladder; ; right lobe of liver; ; left uterine tube; ; Achilles tendon; ; lymph node;
	Top expressed in
	right lung lobe; ; left lung; ; conjunctival fornix; ; left lung lobe; ; blood; ; spleen; ; pharynx; ; thymus; ; trachea; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-18 receptor activity; protein binding; interleukin-1 receptor activity; signaling receptor activity; interleukin-18 binding;
Cellular component	integral component of membrane; plasma membrane; membrane; interleukin-18 receptor complex;
Biological process	natural killer cell activation; positive regulation of interferon-gamma production; T-helper 1 cell differentiation; immune response; signal transduction; interleukin-18-mediated signaling pathway; cellular response to cytokine stimulus; positive regulation of NIK/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of T-helper 1 cell cytokine production; inflammatory response; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8809
	16182
	ENSG00000115604
	ENSMUSG00000026070
	Q13478
	Q61098
NM_001282399; NM_003855; NM_001371418; NM_001371419; NM_001371420;
	NM_001371421; NM_001371422; NM_001371423; NM_001371424
	NM_001161842; NM_001161843; NM_008365
NP_001269328; NP_003846; NP_001358347; NP_001358348; NP_001358349;
	NP_001358350; NP_001358351; NP_001358352; NP_001358353
	NP_001155314; NP_001155315; NP_032391
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.

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