IL17RB

IL17RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VBC
Identifiers
Aliases	IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	OMIM: 605458 MGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,865,794 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	29,730,853 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; kidney; ; right lobe of liver; ; glomerulus; ; amygdala; ; metanephric glomerulus; ; caudate nucleus; ; nucleus accumbens; ; putamen; ; rectum;
	Top expressed in
	secondary oocyte; ; thymus; ; proximal tubule; ; pharynx; ; morula; ; Paneth cell; ; uterus; ; placenta; ; liver; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-17 receptor activity;
Cellular component	cytoplasm; integral component of membrane; extracellular region; cell surface; integral component of plasma membrane; membrane; plasma membrane;
Biological process	defense response; positive regulation of inflammatory response; regulation of cell growth; interleukin-17-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55540
	50905
	ENSG00000056736
	ENSMUSG00000015966
	Q9NRM6
	Q9JIP3
	NM_018725; NM_172234
	NM_019583
	NP_061195
	NP_062529
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.

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