IGFBP7

IGFBP7
Identifiers
Aliases	IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, insulin like growth factor binding protein 7
External IDs	OMIM: 602867 MGI: 1352480 HomoloGene: 1193 GeneCards: IGFBP7
Gene location (Human)
Chr.	Chromosome 4 (human)
End	57,110,385 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,555,888 bp
RNA expression pattern
	Top expressed in
	vena cava; ; renal medulla; ; saphenous vein; ; pericardium; ; superficial temporal artery; ; right coronary artery; ; urethra; ; ascending aorta; ; popliteal artery; ; left coronary artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; proximal tubule; ; renal corpuscle; ; carotid body; ; right lung; ; uterus; ; right lung lobe; ; medullary collecting duct; ; left lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; growth factor binding; insulin-like growth factor binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; extracellular exosome; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen-containing extracellular matrix;
Biological process	regulation of cell growth; negative regulation of cell population proliferation; cell adhesion; response to retinoic acid; cellular response to hormone stimulus; regulation of steroid biosynthetic process; response to heat; embryo implantation; response to organic cyclic compound; response to cortisol; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3490
	29817
	ENSG00000163453
	ENSMUSG00000036256
	Q16270
	Q61581
	NM_001553; NM_001253835
	NM_001159518; NM_008048
	NP_001240764; NP_001544
	NP_001152990; NP_032074
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with low affinity compared to IGFBPs 1-6. It also stimulates cell adhesion. The protein is implicated in some cancers.

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