IGF2BP3

IGF2BP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E44
Identifiers
Aliases	IGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3
External IDs	OMIM: 608259 MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	23,470,491 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	49,191,891 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; placenta; ; embryo; ; sperm; ; ganglionic eminence; ; monocyte; ; retinal pigment epithelium; ; sural nerve; ; stromal cell of endometrium;
	Top expressed in
	primitive streak; ; maxillary prominence; ; somite; ; internal carotid artery; ; medullary collecting duct; ; abdominal wall; ; external carotid artery; ; ureter; ; secondary oocyte; ; hand;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	mRNA 5'-UTR binding; protein binding; translation regulator activity; mRNA 3'-UTR binding; nucleic acid binding; RNA binding;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	anatomical structure morphogenesis; negative regulation of translation; mRNA transport; protein biosynthesis; regulation of translation; regulation of mRNA stability; transport;
	Sources:Amigo / QuickGO
Orthologs
	10643
	140488
	ENSG00000136231
	ENSMUSG00000029814
	O00425
	Q9CPN8
	NM_006547
	NM_023670
	NP_006538
	NP_076159
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.

The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.