ID4

ID4
Identifiers
Aliases	ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
External IDs	OMIM: 600581 MGI: 99414 HomoloGene: 1186 GeneCards: ID4
Gene location (Human)
Chr.	Chromosome 6 (human)
End	19,842,197 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	48,419,502 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; optic nerve; ; hair follicle; ; urethra; ; thyroid gland; ; seminal vesicula; ; left lobe of thyroid gland; ; parietal pleura; ; right lobe of thyroid gland; ; saphenous vein;
	Top expressed in
	olfactory tubercle; ; optic nerve; ; medial dorsal nucleus; ; supraoptic nucleus; ; nucleus accumbens; ; aortic valve; ; globus pallidus; ; utricle; ; ascending aorta; ; suprachiasmatic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; transcription corepressor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor binding;
Cellular component	cytoplasm; nucleus;
Biological process	prostate gland stromal morphogenesis; negative regulation of fat cell differentiation; negative regulation of astrocyte differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; central nervous system myelination; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; seminal vesicle morphogenesis; brain development; positive regulation of gene expression; positive regulation of osteoblast differentiation; prostate gland epithelium morphogenesis; negative regulation of oligodendrocyte differentiation; circadian rhythm; positive regulation of cell population proliferation; prostate gland morphogenesis; neuroblast proliferation; cerebral cortex neuron differentiation; cell population proliferation; negative regulation of transcription, DNA-templated; hippocampus development; fat cell differentiation; positive regulation of transcription by RNA polymerase II; G1/S transition of mitotic cell cycle; neuron differentiation; negative regulation of DNA binding; regulation of cell cycle; osteoblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3400
	15904
	ENSG00000172201
	ENSMUSG00000021379
	P47928
	P41139
	NM_001546
	NM_031166
	NP_001537
	NP_112443
	Wikidata
View/Edit Human	View/Edit Mouse

ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.

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