Hexestrol

Hexestrol
Clinical data
Trade names	Synestrol, Synoestrol, Estrifar, Estronal
Other names	Hexoestrol; Hexanestrol; Hexanoestrol; Dihydrodiethylstilbestrol; Dihydrostilbestrol; 4,4'-(1,2-Diethylethylene)diphenol; NSC-9894
Routes of; administration	By mouth, intramuscular injection (as an ester)
Drug class	Nonsteroidal estrogen
Identifiers
	IUPAC name 4-[4-(4-Hydroxyphenyl)hexan-3-yl]phenol;
CAS Number	84-16-2;
PubChem CID	3606;
IUPHAR/BPS	2823;
DrugBank	DB07931;
ChemSpider	3480;
UNII	10BI795R7D;
KEGG	D01641;
ChEBI	CHEBI:31669;
ChEMBL	ChEMBL6615;
CompTox Dashboard (EPA)	DTXSID2022381 ;
ECHA InfoCard	100.001.380
Chemical and physical data
Formula	C18H22O2
Molar mass	270.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C1=CC=C(C=C1)O)C(CC)C2=CC=C(C=C2)O;
	InChI InChI=1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3; Key:PBBGSZCBWVPOOL-UHFFFAOYSA-N;

Hexestrol, sold under the brand name Synestrol among others, is a nonsteroidal estrogen which was previously used for estrogen replacement therapy and in the treatment of certain hormone-dependent cancers as well as gynecological disorders but is mostly no longer marketed. It has also been used in the form of esters such as hexestrol diacetate (brand name Sintestrol) and hexestrol dipropionate (brand name Hexanoestrol). Hexestrol and its esters are taken by mouth, held under the tongue, or via injection into muscle.

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