Herpesvirus entry mediator

TNFRSF14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMA, 2AW2, 4FHQ, 4RSU
Identifiers
Aliases	TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, tumor necrosis factor receptor superfamily member 14, TNF receptor superfamily member 14
External IDs	OMIM: 602746 MGI: 2675303 HomoloGene: 2833 GeneCards: TNFRSF14
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,565,382 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,013,020 bp
RNA expression pattern
	Top expressed in
	spleen; ; right uterine tube; ; duodenum; ; transverse colon; ; canal of the cervix; ; blood; ; gastric mucosa; ; fundus; ; upper lobe of left lung; ; body of stomach;
	Top expressed in
	thymus; ; yolk sac; ; duodenum; ; lip; ; spleen; ; jejunum; ; blood; ; esophagus; ; stomach; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane;
Biological process	regulation of apoptotic process; T cell costimulation; tumor necrosis factor-mediated signaling pathway; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; regulation of cell population proliferation; immune response; apoptotic signaling pathway; viral entry into host cell; inflammatory response; viral process; negative regulation of alpha-beta T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; positive regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8764
	230979
	ENSG00000273936; ENSG00000157873
	ENSMUSG00000042333
	Q92956
	Q80WM9
	NM_001297605; NM_003820
	NM_178931
	NP_001284534; NP_003811
	NP_849262
	Wikidata
View/Edit Human	View/Edit Mouse

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily encoded by the TNFRSF14 gene.

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