Triazolam

Triazolam
Clinical data
Trade names	Halcion
AHFS/Drugs.com	Monograph
MedlinePlus	a684004
License data	US DailyMed: Triazolam;
Pregnancy; category	AU: C;
Routes of; administration	Oral (by mouth)
ATC code	N05CD05 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); UK: Class C; US: WARNINGSchedule IV; UN: N IV; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	44% (oral route), 53% (sublingual)
Metabolism	Liver
Onset of action	15–30 minutes
Elimination half-life	1.5–5.5 hours
Excretion	Kidney
Identifiers
	IUPAC name 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;
CAS Number	28911-01-5 ;
PubChem CID	5556;
IUPHAR/BPS	7313;
DrugBank	DB00897 ;
ChemSpider	5355 ;
UNII	1HM943223R;
KEGG	D00387 ;
ChEBI	CHEBI:9674 ;
ChEMBL	ChEMBL646 ;
CompTox Dashboard (EPA)	DTXSID6046763 ;
ECHA InfoCard	100.044.811
Chemical and physical data
Formula	C17H12Cl2N4
Molar mass	343.21 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2;
	InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 ; Key:JOFWLTCLBGQGBO-UHFFFAOYSA-N ;
	(verify)

Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives. It possesses pharmacological properties similar to those of other benzodiazepines, but it is generally only used as a sedative to treat severe insomnia. In addition to the hypnotic properties, triazolam's amnesic, anxiolytic, sedative, anticonvulsant, and muscle relaxant properties are pronounced as well.

Triazolam was initially patented in 1970 and went on sale in the United States in 1982. In 2017, it was the 289th most commonly prescribed medication in the United States, with more than one million prescriptions.

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