Major histocompatibility complex, class II, DQ alpha 1

HLA-DQA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JK8, 1S9V, 2NNA, 4GG6, 4OZF, 4OZG, 4OZH, 4OZI
Identifiers
Aliases	HLA-DQA1, CD, CELIAC1, DQ-A1, GSE, HLA-DQA, Major histocompatibility complex, class II, DQ alpha 1, DQA1
External IDs	OMIM: 146880 MGI: 95895 HomoloGene: 123820 GeneCards: HLA-DQA1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,647,062 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,506,797 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; rectum; ; monocyte; ; right lung; ; visceral pleura; ; spleen; ; lymph node; ; upper lobe of left lung; ; appendix; ; right coronary artery;
	Top expressed in
	spleen; ; Paneth cell; ; thymus; ; submandibular gland; ; right lung; ; right lung lobe; ; superior surface of tongue; ; white adipose tissue; ; right ventricle; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide antigen binding; MHC class II receptor activity; protein binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; transport vesicle membrane; integral component of plasma membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; interferon-gamma-mediated signaling pathway; immune system process; T cell costimulation; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; immune response; T cell receptor signaling pathway; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3117
	14960
ENSG00000236418; ENSG00000206305; ENSG00000225890; ENSG00000232062; ENSG00000196735;
	ENSG00000228284
	ENSMUSG00000036594
	P01909
P14434; P14437; P01910; P14435; P14438;
	P04228; P14436; P04227
	NM_002122
	NM_010378
	NP_002113
	NP_034508
	Wikidata
View/Edit Human	View/Edit Mouse

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

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