HLA-DMA

HLA-DMA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HDM, 2BC4, 4FQX, 4GBX
Identifiers
Aliases	HLA-DMA, D6S222E, DMA, HLADM, RING6, major histocompatibility complex, class II, DM alpha
External IDs	OMIM: 142855 MGI: 95921 HomoloGene: 4464 GeneCards: HLA-DMA
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,969,094 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,358,075 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lymph node; ; spleen; ; appendix; ; gallbladder; ; upper lobe of left lung; ; right lung; ; duodenum; ; rectum; ; subcutaneous adipose tissue;
	Top expressed in
	spleen; ; thymus; ; blood; ; subcutaneous adipose tissue; ; jejunum; ; Paneth cell; ; sciatic nerve; ; ankle joint; ; lip; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class II protein complex binding; protein binding;
Cellular component	integral component of membrane; cell surface; endosome; lysosome; extracellular exosome; late endosome membrane; membrane; lysosomal membrane; MHC class II protein complex; intracellular membrane-bounded organelle;
Biological process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; immune system process; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3108
	14998
ENSG00000243215; ENSG00000243719; ENSG00000239463; ENSG00000204257; ENSG00000242361;
	ENSG00000241394; ENSG00000243189; ENSG00000242685
	ENSMUSG00000037649
	P28067
	P28078; Q31621
	NM_006120
	NM_010386; NM_001360530
	n/a
	NP_034516; NP_001347459
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

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