HADHB

HADHB
Identifiers
Aliases	HADHB, ECHB, MSTP029, MTPB, TP-BETA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
External IDs	OMIM: 143450 MGI: 2136381 HomoloGene: 153 GeneCards: HADHB
Gene location (Human)
Chr.	Chromosome 2 (human)
End	26,290,465 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	30,389,591 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; deltoid muscle; ; tibialis anterior muscle; ; jejunal mucosa; ; gastrocnemius muscle; ; triceps brachii muscle; ; quadriceps femoris muscle; ; biceps brachii; ; vastus lateralis muscle; ; thoracic diaphragm;
	Top expressed in
	spermatocyte; ; esophagus; ; spermatid; ; lip; ; yolk sac; ; superior frontal gyrus; ; morula; ; duodenum; ; proximal tubule; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; enoyl-CoA hydratase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; protein binding; catalytic activity; acyltransferase activity; 3-hydroxyacyl-CoA dehydrogenase activity; RNA binding; acetyl-CoA C-acyltransferase activity; long-chain-enoyl-CoA hydratase activity;
Cellular component	membrane; mitochondrial outer membrane; endoplasmic reticulum; mitochondrial inner membrane; mitochondrial envelope; mitochondrial nucleoid; extracellular exosome; mitochondrion;
Biological process	lipid metabolism; fatty acid metabolic process; metabolism; cardiolipin acyl-chain remodeling; fatty acid beta-oxidation;
	Sources:Amigo / QuickGO
Orthologs
	3032
	231086
	ENSG00000138029
	ENSMUSG00000059447
	P55084
	Q99JY0
	NM_000183; NM_001281512; NM_001281513
	NM_145558; NM_001289798; NM_001289799
	NP_000174; NP_001268441; NP_001268442
	NP_001276727; NP_001276728; NP_663533
	Wikidata
View/Edit Human	View/Edit Mouse

Trifunctional enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene.

HADHB is a subunit of the mitochondrial trifunctional protein and has thiolase activity.

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