Histamine H₁ receptor

HRH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RZE
Identifiers
Aliases	HRH1, H1-R, H1R, HH1R, hisH1, histamine receptor H1
External IDs	OMIM: 600167 MGI: 107619 HomoloGene: 668 GeneCards: HRH1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	11,263,557 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	114,460,257 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; mucosa of urinary bladder; ; synovial membrane; ; ascending aorta; ; synovial joint; ; stromal cell of endometrium; ; endothelial cell; ; spinal ganglia; ; pericardium; ; gallbladder;
	Top expressed in
	ventromedial nucleus; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; suprachiasmatic nucleus; ; pontine nuclei; ; dorsomedial hypothalamic nucleus; ; medial dorsal nucleus; ; lateral hypothalamus; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histamine receptor activity; signal transducer activity; G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; cytosol; dendrite;
Biological process	eosinophil chemotaxis; inositol phosphate-mediated signaling; regulation of vasoconstriction; positive regulation of inositol trisphosphate biosynthetic process; cellular response to histamine; regulation of vascular permeability; phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of synaptic plasticity; G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; inflammatory response; visual learning; signal transduction; memory; positive regulation of vasoconstriction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3269
	15465
	ENSG00000196639
	ENSMUSG00000053004
	P35367
	P70174
	NM_000861; NM_001098211; NM_001098212; NM_001098213
NM_001252642; NM_001252643; NM_008285; NM_001317124; NM_001317125;
	NM_001317126
	NP_000852; NP_001091681; NP_001091682; NP_001091683
NP_001239571; NP_001239572; NP_001304053; NP_001304054; NP_001304055;
	NP_032311
	Wikidata
View/Edit Human	View/Edit Mouse

The H₁ receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. The H₁ receptor is linked to an intracellular G-protein (G_q) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs. The crystal structure of the receptor has been determined (shown on the right/below) and used to discover new histamine H₁ receptor ligands in structure-based virtual screening studies.

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Histamine H1 receptor

Histamine H₁ receptor