Guanidinium thiocyanate

Guanidinium thiocyanate (GTC) or guanidinium isothiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used as a nucleic acid protector in the extraction of DNA and RNA from cells.

Guanidinium thiocyanate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.008.922
EC Number
  • 209-812-1
UNII
  • InChI=1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H Y
    Key: ZJYYHGLJYGJLLN-UHFFFAOYSA-N Y
  • InChI=1/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
    Key: ZJYYHGLJYGJLLN-UHFFFAOYAS
  • N#CS.[N@H]=C(N)N
Properties
C2H6N4S
Molar mass 118.16 g·mol−1
Hazards
GHS labelling:
Danger
H302, H312, H314, H332, H412
P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, P501
Safety data sheet (SDS) External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

GITC may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation, [CH6N3]+.

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