Gonadotropin-releasing hormone receptor
The gonadotropin-releasing hormone receptor (GnRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is the receptor of gonadotropin-releasing hormone (GnRH). The GnRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.
| Gonadotropin-releasing hormone receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GNRHR | ||||||
| Alt. symbols | GnRH-R; LRHR; | ||||||
| NCBI gene | 2798 | ||||||
| HGNC | 4421 | ||||||
| OMIM | 138850 | ||||||
| RefSeq | NM_000406 | ||||||
| UniProt | P30968 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q21.2 | ||||||
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| Gonadotropin-releasing hormone (type 2) receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GNRHR2 | ||||||
| NCBI gene | 114814 | ||||||
| HGNC | 16341 | ||||||
| RefSeq | NR_002328 | ||||||
| UniProt | Q96P88 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q12 | ||||||
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This receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of GnRH after its release from the hypothalamus. Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary.
Evidence exists showing the presence of GnRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.