Trifunctional purine biosynthetic protein adenosine-3

GART
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MEJ, 1MEN, 1MEO, 1NJS, 1RBM, 1RBQ, 1RBY, 1RBZ, 1RC0, 1RC1, 1ZLX, 1ZLY, 2QK4, 2V9Y, 4EW1, 4EW2, 4EW3, 4ZZ2, 4ZZ3, 4ZZ1, 4ZYV, 4ZZ0, 4ZYY, 4ZYX, 4ZYZ, 4ZYT, 4ZYU, 4ZYW
Identifiers
Aliases	GART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
External IDs	OMIM: 138440 MGI: 95654 HomoloGene: 637 GeneCards: GART
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,543,491 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,443,840 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; rectum; ; smooth muscle tissue; ; body of pancreas; ; gastric mucosa; ; spongy bone; ; islet of Langerhans; ; thymus; ; lymph node; ; Achilles tendon;
	Top expressed in
	primitive streak; ; yolk sac; ; somite; ; extraocular muscle; ; morula; ; maxillary prominence; ; otic placode; ; abdominal wall; ; renal corpuscle; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; phosphoribosylglycinamide formyltransferase activity; metal ion binding; ligase activity; catalytic activity; hydroxymethyl-, formyl- and related transferase activity; ATP binding; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylamine-glycine ligase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	purine nucleotide biosynthetic process; glycine metabolic process; 'de novo' IMP biosynthetic process; brainstem development; biosynthesis; response to organic substance; cerebellum development; ribonucleoside monophosphate biosynthetic process; tetrahydrofolate biosynthetic process; response to inorganic substance; purine ribonucleoside monophosphate biosynthetic process; cerebral cortex development; metabolism; purine nucleobase biosynthetic process; adenine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2618
	14450
	ENSG00000262473; ENSG00000159131
	ENSMUSG00000022962
	P22102
	Q64737
	NM_000819; NM_001136005; NM_001136006; NM_175085
	NM_010256; NM_001357351
	NP_000810; NP_001129477; NP_001129478; NP_780294
	NP_034386; NP_001344280
	Wikidata
View/Edit Human	View/Edit Mouse

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene.

This protein is a trifunctional polypeptide. It has phosphoribosylamine—glycine ligase (EC 6.3.4.13), phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), AIR synthetase (FGAM cyclase) (EC 6.3.3.1) activity which is required for de novo purine biosynthesis.

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