Glyceraldehyde 3-phosphate dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) (EC 1.2.1.12) is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, ER to Golgi vesicle shuttling, and fast axonal, or axoplasmic transport. In sperm, a testis-specific isoenzyme GAPDHS is expressed.
| Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain | |||||||||
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determinants of enzyme thermostability observed in the molecular structure of thermus aquaticus d-glyceraldehyde-3-phosphate dehydrogenase at 2.5 angstroms resolution | |||||||||
| Identifiers | |||||||||
| Symbol | Gp_dh_N | ||||||||
| Pfam | PF00044 | ||||||||
| Pfam clan | CL0063 | ||||||||
| InterPro | IPR020828 | ||||||||
| PROSITE | PDOC00069 | ||||||||
| SCOP2 | 1gd1 / SCOPe / SUPFAM | ||||||||
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| Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain | |||||||||
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crystal structure of glyceraldehyde-3-phosphate dehydrogenase from pyrococcus horikoshii ot3 | |||||||||
| Identifiers | |||||||||
| Symbol | Gp_dh_C | ||||||||
| Pfam | PF02800 | ||||||||
| Pfam clan | CL0139 | ||||||||
| InterPro | IPR020829 | ||||||||
| PROSITE | PDOC00069 | ||||||||
| SCOP2 | 1gd1 / SCOPe / SUPFAM | ||||||||
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