Glucose-dependent insulinotropic polypeptide

GIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L71, 2B4N, 2OBU, 2QKH, 2L70, 1T5Q
Identifiers
Aliases	GIP, gastric inhibitory polypeptide
External IDs	OMIM: 137240 MGI: 107504 HomoloGene: 3043 GeneCards: GIP
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,968,596 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,921,657 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; pancreatic ductal cell; ; stromal cell of endometrium; ; sural nerve; ; placenta; ; liver; ; kidney; ; testicle; ; cecum;
	Top expressed in
	duodenum; ; crypt of lieberkuhn of small intestine; ; jejunum; ; intestinal epithelium; ; intestinal villus; ; retinal pigment epithelium; ; morula; ; corneal stroma; ; ileum; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; protein binding; signaling receptor binding;
Cellular component	cytoplasm; endoplasmic reticulum lumen; extracellular region; neuronal cell body; secretory granule lumen; extracellular space;
Biological process	response to selenium ion; response to amino acid; response to organic cyclic compound; digestive system development; regulation of insulin secretion; adult locomotory behavior; female pregnancy; response to peptide hormone; positive regulation of cAMP-mediated signaling; memory; response to glucose; response to lipid; response to nutrient levels; positive regulation of synaptic transmission; exploration behavior; response to axon injury; response to starvation; sensory perception of pain; positive regulation of glucagon secretion; positive regulation of glucose transmembrane transport; response to carbohydrate; triglyceride homeostasis; signal transduction; response to acidic pH; endocrine pancreas development; positive regulation of insulin secretion; long-term potentiation; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; regulation of fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2695
	14607
	ENSG00000159224
	ENSMUSG00000014351
	P09681
	P48756
	NM_004123
	NM_008119
	NP_004114
	NP_032145
	Wikidata
View/Edit Human	View/Edit Mouse

Glucose-dependent insulinotropic polypeptide (more commonly known earlier as gastric inhibitory polypeptide or gastric inhibitory peptide), abbreviated as GIP, is an inhibiting hormone of the secretin family of hormones. While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion.

GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins, which stimulate insulin release on oral food intake.

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