Glycogen synthase kinase-3 beta

GSK3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN
Identifiers
Aliases	GSK3B, Gsk3b, 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3, glycogen synthase kinase 3 beta
External IDs	OMIM: 605004 MGI: 1861437 HomoloGene: 55629 GeneCards: GSK3B
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	120,094,994 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	38,066,446 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; ganglionic eminence; ; postcentral gyrus; ; superior frontal gyrus; ; corpus epididymis; ; islet of Langerhans; ; middle temporal gyrus; ; monocyte; ; blood;
	Top expressed in
	spermatid; ; cumulus cell; ; ventromedial nucleus; ; lateral hypothalamus; ; mammillary body; ; retinal pigment epithelium; ; lateral geniculate nucleus; ; Region I of hippocampus proper; ; primary motor cortex; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; ATP binding; protein kinase activity; protein kinase A catalytic subunit binding; protein serine/threonine kinase activity; transferase activity; NF-kappaB binding; tau-protein kinase activity; protein binding; nucleotide binding; p53 binding; ubiquitin protein ligase binding; protease binding; beta-catenin binding; protein kinase binding; dynactin binding; tau protein binding;
Cellular component	cytoplasm; membrane; mitochondrion; nucleus; centrosome; plasma membrane; cytosol; beta-catenin destruction complex; postsynapse; Wnt signalosome; nucleoplasm; axon; dendrite; glutamatergic synapse;
Biological process	rhythmic process; negative regulation of type B pancreatic cell development; negative regulation of protein binding; negative regulation of glycogen (starch) synthase activity; glycogen metabolic process; superior temporal gyrus development; negative regulation of canonical Wnt signaling pathway; chemical synaptic transmission, postsynaptic; negative regulation of protein-containing complex assembly; positive regulation of protein export from nucleus; positive regulation of GTPase activity; protein autophosphorylation; cell differentiation; negative regulation of protein localization to nucleus; phosphorylation; positive regulation of cell-matrix adhesion; nervous system development; dopamine receptor signaling pathway; epithelial to mesenchymal transition; peptidyl-threonine phosphorylation; positive regulation of protein-containing complex assembly; positive regulation of neuron death; negative regulation of glycogen biosynthetic process; multicellular organism development; regulation of cellular response to heat; negative regulation of signal transduction; hippocampus development; beta-catenin destruction complex disassembly; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway; beta-catenin destruction complex assembly; protein phosphorylation; positive regulation of mitochondrion organization; intracellular signal transduction; positive regulation of protein catabolic process; negative regulation of dopaminergic neuron differentiation; ER overload response; circadian rhythm; peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of microtubule-based process; cellular response to interleukin-3; negative regulation of apoptotic process; canonical Wnt signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; carbohydrate metabolic process; neuron projection development; negative regulation of neuron death; positive regulation of gene expression; establishment of cell polarity; maintenance of cell polarity; regulation of axon extension; negative regulation of phosphoprotein phosphatase activity; regulation of dendrite morphogenesis; regulation of axonogenesis; excitatory postsynaptic potential; regulation of microtubule cytoskeleton organization; negative regulation of calcineurin-NFAT signaling cascade; extrinsic apoptotic signaling pathway; neuron projection retraction; negative regulation of protein acetylation; cellular response to amyloid-beta; positive regulation of protein localization to centrosome; regulation of synaptic vesicle exocytosis; neuron projection organization; positive regulation of autophagy; regulation of circadian rhythm; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome;
	Sources:Amigo / QuickGO
Orthologs
	2932
	56637
	ENSG00000082701
	ENSMUSG00000022812
	P49841
	Q9WV60
	NM_001146156; NM_002093; NM_001354596
	NM_019827; NM_001347232
	NP_001139628; NP_002084; NP_001341525
	NP_001334161; NP_062801
	Wikidata
View/Edit Human	View/Edit Mouse

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.

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