GSK3A

GSK3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DFM
Identifiers
Aliases	GSK3A, Gsk3a, 2700086H06Rik, glycogen synthase kinase 3 alpha
External IDs	OMIM: 606784 MGI: 2152453 HomoloGene: 88581 GeneCards: GSK3A
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,242,625 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,937,276 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; cingulate gyrus; ; amygdala; ; anterior pituitary; ; Brodmann area 9; ; nucleus accumbens; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; putamen;
	Top expressed in
	motor neuron; ; primary motor cortex; ; superior colliculus; ; subiculum; ; piriform cortex; ; cingulate gyrus; ; pontine nuclei; ; dorsal tegmental nucleus; ; globus pallidus; ; olfactory tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; protein binding; ATP binding; protein kinase binding; protein kinase A catalytic subunit binding; signaling receptor binding; tau protein binding;
Cellular component	cytosol; beta-catenin destruction complex; postsynapse; mitochondrion; cytoplasm; microtubule; neuronal cell body; apical dendrite; proximal dendrite;
Biological process	positive regulation of protein catabolic process; phosphorylation; positive regulation of protein targeting to mitochondrion; chemical synaptic transmission, postsynaptic; negative regulation of UDP-glucose catabolic process; negative regulation of type B pancreatic cell development; Wnt signaling pathway; negative regulation of glycogen biosynthetic process; nervous system development; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; dopamine receptor signaling pathway; protein phosphorylation; IRE1-mediated unfolded protein response; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; regulation of autophagy of mitochondrion; negative regulation of glycogen (starch) synthase activity; cellular response to insulin stimulus; glycogen metabolic process; negative regulation of signal transduction; negative regulation of canonical Wnt signaling pathway; regulation of systemic arterial blood pressure; cardiac left ventricle morphogenesis; regulation of gene expression by genetic imprinting; human ageing; insulin receptor signaling pathway; positive regulation of peptidyl-threonine phosphorylation; cell migration; negative regulation of TOR signaling; positive regulation of peptidyl-serine phosphorylation; cellular response to interleukin-3; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of neuron apoptotic process; hypermethylation of CpG island; positive regulation of heart contraction; positive regulation of transcription by RNA polymerase II; negative regulation of cell growth involved in cardiac muscle cell development; cellular response to lithium ion; cellular response to organic cyclic compound; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of dendrite development; positive regulation of glycogen (starch) synthase activity; carbohydrate metabolic process; positive regulation of gene expression; peptidyl-threonine phosphorylation; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of amyloid-beta formation; positive regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	2931
	606496
	ENSG00000105723
	ENSMUSG00000057177
	P49840
	Q2NL51
	NM_019884
	NM_001031667
	NP_063937
	NP_001026837
	Wikidata
View/Edit Human	View/Edit Mouse

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.

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