NAGly receptor

GPR18
Identifiers
Aliases	GPR18, G protein-coupled receptor 18
External IDs	OMIM: 602042 MGI: 107859 HomoloGene: 18814 GeneCards: GPR18
Gene location (Human)
Chr.	Chromosome 13 (human)
End	99,261,744 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	122,153,193 bp
RNA expression pattern
	Top expressed in
	sperm; ; lymph node; ; thymus; ; blood; ; appendix; ; spleen; ; bone marrow; ; monocyte; ; Achilles tendon; ; jejunal mucosa;
	Top expressed in
	spleen; ; blood; ; subcutaneous adipose tissue; ; morula; ; thymus; ; jejunum; ; white adipose tissue; ; duodenum; ; Paneth cell; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	signal transduction; CD8-positive, alpha-beta intraepithelial T cell differentiation; negative regulation of tumor necrosis factor production; CD8-positive, gamma-delta intraepithelial T cell differentiation; negative regulation of leukocyte chemotaxis; T cell differentiation; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2841
	110168
	ENSG00000125245
	ENSMUSG00000050350
	Q14330
	Q8K1Z6
	NM_001098200; NM_005292
	NM_182806
	NP_001091670; NP_005283
	NP_877958
	Wikidata
View/Edit Human	View/Edit Mouse

N-Arachidonyl glycine receptor (NAGly receptor), also known as G protein-coupled receptor 18 (GPR18), is a protein that in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. It has been found to be involved in the regulation of intraocular pressure.

Research supports the hypothesis that GPR18 is the abnormal cannabidiol receptor and N-arachidonoyl glycine, the endogenous lipid metabolite of anandamide, initiates directed microglial migration in the CNS through activation of GPR18, though recent evidence demonstrates that NAGly was not shown to be a GPR18 agonist in rat sympathetic neurons.

Resolvin D2 (RvD2), a member of the specialized proresolving mediators (SPM) class of polyunsaturated fatty acid metabolites, is an activating ligand for GPR18; RvD2 and its activation of GPR18 contribute to the resolution of inflammatory responses as well as inflammation-based and other diseases in animal models and are proposed to do so in humans. Furthermore, RvD2 is a metabolite of the omega-3 fatty acid, docosahexaenoic acid (DHA); the metabolism of DHA to RvD2 and RvD2's activation of GPR18 is proposed to one among many other mechanisms for the anti-inflammatory and other beneficial effects attributed to omega-3 fatty acid-rich diets

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