GPER

GPER1
Identifiers
Aliases	GPER1, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 1
External IDs	OMIM: 601805 MGI: 1924104 HomoloGene: 15855 GeneCards: GPER1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,093,815 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,413,555 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; middle frontal gyrus; ; fundus; ; frontal pole; ; right lobe of liver; ; putamen; ; cardia; ; internal globus pallidus; ; amygdala; ; cingulate gyrus;
	Top expressed in
	external carotid artery; ; otolith organ; ; utricle; ; internal carotid artery; ; condyle; ; fossa; ; trigeminal ganglion; ; epithelium of stomach; ; substantia nigra; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	estrogen receptor activity; steroid hormone binding; chromatin binding; protein binding; signal transducer activity; steroid binding; G protein-coupled receptor activity; steroid hormone receptor activity;
Cellular component	cytoplasm; endosome; nuclear envelope; membrane; synapse; trans-Golgi network; mitochondrion; perinuclear region of cytoplasm; cytoskeleton; nucleus; cell projection; mitochondrial membranes; keratin filament; dendritic shaft; dendritic spine head; endoplasmic reticulum; dendritic spine membrane; integral component of membrane; recycling endosome; Golgi apparatus; plasma membrane; intracellular anatomical structure; presynaptic active zone; axon; early endosome; axon terminus; endoplasmic reticulum membrane; postsynaptic density; Golgi membrane; integral component of plasma membrane; cell junction; dendrite; cytoplasmic vesicle membrane; presynaptic membrane; cytoplasmic vesicle; hippocampal mossy fiber to CA3 synapse;
Biological process	positive regulation of protein phosphorylation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; cell cycle; negative regulation of inflammatory response; cellular response to glucose stimulus; steroid hormone mediated signaling pathway; negative regulation of cell population proliferation; apoptotic process; negative regulation of fat cell differentiation; negative regulation of leukocyte activation; apoptotic chromosome condensation; regulation of cytosolic calcium ion concentration; positive regulation of neurotransmitter secretion; negative regulation of gene expression; nuclear fragmentation involved in apoptotic nuclear change; positive regulation of endothelial cell apoptotic process; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of cardiac vascular smooth muscle cell differentiation; innate immune response; inflammatory response; positive regulation of MAPK cascade; G protein-coupled receptor signaling pathway; negative regulation of protein kinase B signaling; cell differentiation; immune system process; negative regulation of cell cycle process; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of lipid biosynthetic process; nervous system development; positive regulation of neurogenesis; positive regulation of release of cytochrome c from mitochondria; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of insulin secretion; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; cellular response to estradiol stimulus; cellular response to peptide hormone stimulus; positive regulation of gene expression; cellular response to mineralocorticoid stimulus; positive regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of DNA metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of uterine smooth muscle contraction; neuronal action potential; signal transduction; mineralocorticoid receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of apoptotic process; intracellular steroid hormone receptor signaling pathway; positive regulation of protein localization to plasma membrane; adenylate cyclase-activating G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2852
	76854
	ENSG00000164850
	ENSMUSG00000053647
	Q99527
	Q8BMP4
	NM_001031682; NM_001039966; NM_001098201; NM_001505
	NM_029771
	NP_001035055; NP_001091671; NP_001496
	NP_084047
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene. GPER binds to and is activated by the female sex hormone estradiol and is responsible for some of the rapid effects that estradiol has on cells.

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