GNAQ

GNAQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BCJ, 2RGN, 3AH8, 3OHM, 4EKC, 4EKD, 4GNK, 4QJ3, 4QJ4, 4QJ5
Identifiers
Aliases	GNAQ, CMC1, G-ALPHA-q, GAQ, SWS, G protein subunit alpha q
External IDs	OMIM: 600998 MGI: 95776 HomoloGene: 1566 GeneCards: GNAQ
Gene location (Human)
Chr.	Chromosome 9 (human)
End	78,031,811 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	16,364,827 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; postcentral gyrus; ; inferior olivary nucleus; ; Brodmann area 46; ; entorhinal cortex; ; orbitofrontal cortex; ; subthalamic nucleus; ; external globus pallidus; ; superior vestibular nucleus; ; cardia;
	Top expressed in
	ventromedial nucleus; ; arcuate nucleus; ; mammillary body; ; paraventricular nucleus of hypothalamus; ; substantia nigra; ; ventral tegmental area; ; lateral hypothalamus; ; subiculum; ; medial geniculate nucleus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; type 2A serotonin receptor binding; GTPase activator activity; GTP binding; metal ion binding; protein binding; GTPase activity; guanyl nucleotide binding; G protein-coupled receptor binding; signal transducer activity; G-protein beta/gamma-subunit complex binding;
Cellular component	cytoplasm; cell body; nuclear membrane; membrane; plasma membrane; photoreceptor outer segment; lysosomal membrane; dendrite; extracellular exosome; nucleus; heterotrimeric G-protein complex; intracellular anatomical structure;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; skeletal system development; negative regulation of protein kinase activity; neuron remodeling; embryonic digit morphogenesis; protein stabilization; blood coagulation; post-embryonic development; regulation of melanocyte differentiation; activation of phospholipase C activity; entrainment of circadian clock; platelet activation; forebrain neuron development; heart development; maternal behavior; phototransduction, visible light; developmental pigmentation; signal transduction; positive regulation of GTPase activity; glutamate receptor signaling pathway; action potential; adenylate cyclase-activating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2776
	14682
	ENSG00000156052
	ENSMUSG00000024639
	P50148
	P21279
	NM_002072
	NM_008139
	NP_002063; NP_002063.2
	NP_032165
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it functions as a Gq alpha subunit.

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