GAS6

GAS6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H30, 2C5D, 4RA0
Identifiers
Aliases	GAS6, AXLLG, AXSF, growth arrest specific 6
External IDs	OMIM: 600441 MGI: 95660 HomoloGene: 638 GeneCards: GAS6
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,864,076 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,544,490 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right uterine tube; ; right coronary artery; ; canal of the cervix; ; left uterine tube; ; popliteal artery; ; tibial nerve; ; left coronary artery; ; gastric mucosa; ; skin of abdomen;
	Top expressed in
	calvaria; ; gallbladder; ; ankle; ; lip; ; epithelium of stomach; ; right lung; ; fundus; ; cervix; ; right lung lobe; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor binding; receptor tyrosine kinase binding; voltage-gated calcium channel activity; receptor ligand activity; molecular adaptor activity; phosphatidylserine binding; metal ion binding; protein tyrosine kinase activator activity; calcium ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein-macromolecule adaptor activity;
Cellular component	endoplasmic reticulum lumen; cytoplasm; Golgi lumen; platelet alpha granule lumen; extracellular exosome; extracellular region; intracellular anatomical structure; extracellular space;
Biological process	positive regulation of natural killer cell differentiation; apoptotic cell clearance; cellular response to vitamin K; negative regulation of DNA-binding transcription factor activity; positive regulation of protein kinase activity; negative regulation of biomineral tissue development; negative regulation of tumor necrosis factor-mediated signaling pathway; cellular response to starvation; positive regulation of phagocytosis; positive regulation of protein kinase B signaling; positive regulation of cytokine-mediated signaling pathway; positive regulation of gene expression; dendritic cell differentiation; neuron migration; cell adhesion; protein kinase B signaling; positive regulation of glomerular filtration; B cell chemotaxis; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; phagocytosis; regulation of growth; activation of protein kinase B activity; negative regulation of tumor necrosis factor production; platelet degranulation; viral entry into host cell; negative regulation of oligodendrocyte apoptotic process; leukocyte migration; enzyme linked receptor protein signaling pathway; positive regulation of protein tyrosine kinase activity; cell migration; platelet activation; negative regulation of transcription, DNA-templated; positive regulation of protein export from nucleus; animal organ regeneration; cellular response to growth factor stimulus; negative regulation of interferon-gamma production; macrophage cytokine production; cellular response to glucose stimulus; hematopoietic stem cell migration to bone marrow; negative regulation of dendritic cell apoptotic process; calcium ion transmembrane transport; cell-substrate adhesion; negative regulation of interleukin-6 production; positive regulation of dendritic cell chemotaxis; signal peptide processing; viral genome replication; cell population proliferation; positive regulation of fibroblast proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of fibroblast apoptotic process; positive regulation of peptidyl-serine phosphorylation; platelet aggregation; positive regulation of TOR signaling; peptidyl-serine phosphorylation; endoplasmic reticulum to Golgi vesicle-mediated transport; viral process; extracellular matrix assembly; cellular response to interferon-alpha; protein phosphorylation; negative regulation of renal albumin absorption; negative regulation of endothelial cell apoptotic process; positive regulation of protein phosphorylation; signal transduction; blood coagulation; apoptotic process; post-translational protein modification; protein localization to plasma membrane; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2621
	14456
	ENSG00000183087
	ENSMUSG00000031451
	Q14393
	Q61592
	NM_001143946; NM_000820; NM_001143945
	NM_019521
	NP_000811
	NP_062394
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

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