Granulocyte colony-stimulating factor receptor

CSF3R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9Q
Identifiers
Aliases	CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7
External IDs	OMIM: 138971 MGI: 1339755 HomoloGene: 601 GeneCards: CSF3R
Gene location (Human)
Chr.	Chromosome 1 (human)
End	36,483,278 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,938,233 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; upper lobe of left lung; ; right lung; ; spleen; ; bone marrow cells; ; placenta; ; lower lobe of lung; ; spongy bone; ; appendix;
	Top expressed in
	blood; ; blastocyst; ; bone marrow; ; morula; ; spleen; ; right lung; ; right lung lobe; ; body of femur; ; neuron; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein binding; granulocyte colony-stimulating factor binding; signaling receptor activity; interleukin-3 receptor activity; cytokine binding; interleukin-3 binding;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane; external side of plasma membrane; receptor complex;
Biological process	defense response; cell adhesion; regulation of myeloid cell differentiation; neutrophil chemotaxis; signal transduction; amelogenesis; cytokine-mediated signaling pathway; cellular response to interleukin-3; interleukin-3-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1441
	12986
	ENSG00000119535
	ENSMUSG00000028859
	Q99062
	P40223
	NM_000760; NM_156038; NM_156039; NM_172313
	NM_001252651; NM_007782
	NP_000751; NP_724781; NP_758519
	NP_001239580; NP_031808
	Wikidata
View/Edit Human	View/Edit Mouse

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belong to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

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